Job Description

Ready to redefine what's possible in molecular diagnostics?

Join a team of brilliant, passionate innovators who wake up every day determined to transform healthcare. At BillionToOne, we've built something extraordinarya culture where transparency fuels trust, collaboration drives breakthroughs, and every voice matters in our mission to make life-changing diagnostics accessible to all. We don't just aim for incremental improvements; we strive to build products that are 10x better than anything that exists today.Our people are our greatest asset:talented scientists, engineers, sales professionals, and visionaries united by an unwavering commitment to changing the standard of care in prenatal and cancer diagnostics. This is where cutting-edge science meets human compassionevery innovation you contribute helps remove fear of unknown from some of life's most critical medical moments. If you're driven by purpose, energized by innovation, and ready to help build the future of precision medicine, this is where you belong.

We are seeking an experienced and highly skilled Molecular Genetics Clinical Laboratory Director Oncology or Senior Laboratory Director Oncology to provide technical leadership and oversee the daily operations of our high-complexity oncology clinical laboratory. The Oncology Lab Director is responsible for ensuring accurate interpretation and reporting of oncology test results, maintaining regulatory compliance, driving quality improvements, and collaborating cross-functionally to advance our oncology assays. This is a full-time, onsite role (2-3 days/week) in Menlo Park, CA.

Responsibilities:

• Provide technical oversight to ensure high-quality oncology testing and alignment with laboratory and clinical goals.
• Interpret somatic variant results from Northstar liquid biopsy assays, classify variants, and sign out oncology clinical reports.
• Troubleshoot technical issues related to oncology workflows, including liquid biopsy sample prep, NGS library preparation, sequencing, and data analysis.
• Evaluate lab performance, implement process improvements, and promote robust quality assurance systems.
• Review Non-Conforming Events and CAPAs to ensure timely resolution of issues impacting oncology test performance.
• Ensure compliance with CLIA, CAP, NYSDOH, and other applicable regulatory standards for oncology assays.
• Oversee accurate documentation of SOPs, validation reports, QC records, personnel competencies, proficiency testing, and report archives.
• Collaborate with bioinformatics, R&D, and medical affairs on assay development, interpretation guidelines, and continuous assay optimization.
• Participate in budget planning and manage lab expenses to ensure financial efficiency while maintaining exceptional quality.
• Support special projects, including scaling new oncology tests, preparing for inspections, and implementing automation.
• Serve as a subject matter expert on oncology variant interpretation, including AMP/CAP/NYS guidelines.

Requirements:

• Doctoral degree (PhD, MD, or equivalent) in genetics, molecular biology, or a related field.
• Board certification (ABMGG, ABP in Molecular Genetic Pathology, or equivalent).
• Valid or eligible for California Clinical Laboratory Director license (CGMB, CGMBS, MD/DO licensure) and New York State CoQ in oncology testing.
• 4+ years in a regulated clinical laboratory environment (CLIA/CAP/NYSDOH), with at least 3 years in molecular oncology testing including NGS.
• Proven leadership in developing, validating, and implementing oncology assays (e.g., somatic mutation panels, methylation assays).
• Deep knowledge of cancer genomics, including tumor heterogeneity, somatic driver mutations, and targeted therapies.
• Experience with variant interpretation databases (COSMIC, OncoKB, ClinVar), IGV, BAM file review, and molecular tumor board participation.
• Strong analytical, communication, and organizational skills, with a track record of leading teams in high-growth environments.
• Proficiency with LIMS and oncology-focused bioinformatics tools.
• Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousands patients
• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
• Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
• Supplemental fertility benefits coverage
• Retirement savings program including a 4% Company match
• Increase paid time off with increased tenure
• Latest and greatest hardware (laptop, lab equipment, facilities)
• Free daily on-site lunches provided from top eateries
• A variety of perks on campus (state of the art gym, restaurant)
• Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.).

For this position, we offer a total compensation package of up to $462,120 per year, including a base pay range of $213,282 - $260,100 per year.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

For more information about how we protect your information, we encourage you to review our Privacy Policy .

About BillionToOne

BillionToOne is a next-generation molecular diagnostics company on a mission to make powerful, accurate diagnostic tests accessible to everyone. Our revolutionary QCT molecular counting technology enhances disease detection resolution by over a thousandfold using cell-free DNAa breakthrough that's already transformed the lives of over half a million patients worldwide.

Our Impact: We've pioneered game-changing diagnostic solutions that are redefining industry standards. Unity Complete stands as the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. In oncology, our Northstar liquid biopsy test uniquely combines treatment selection with real-time monitoring, giving oncologists unprecedented precision in cancer care.

Our Growth: From $0 to $125 million in Annual Recurring Revenue in just four years. We've raised close to $400 million in funding, including a $130 million Series D round in June 2024, achieving a valuation of over $1 billion. This backing comes from world-class investors including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest.

Our Recognition: Forbes recently named us one of America's Best Startup Employers for 2025 , and we were awarded Great Place to Work certification in 2024 with an incredible 100% of our people reporting they are willing to give extra to get the job done . These honors recognize not just our innovation but the exceptional culture we've cultivatedone that remains authentically collaborative and transparent even as we've scaled.

Our Future: Headquartered in Menlo Park with facilities in Union City, California, we're continuing to push the boundaries of what's possible in molecular diagnostics. Recent clinical outcomes data for Unity Fetal Risk Screen and new advances in cancer diagnostics prove we're just getting started.

At BillionToOne, you'll join a diverse team of passionate innovators who believe that the best science happens when brilliant minds collaborate openly, think boldly, and never lose sight of the patients whose lives depend on our work.

Ready to help us change the world, one diagnosis at a time?

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Do you have board certification from the American Board of Medical Genetics and Genomics (ABMGG), or equivalent? If so, list certification. *

Do you have clinical laboratory license from the California Department of Public Health or a California Medical License? If so, list licensure. *

Do you have at least 4+ years of experience working in a regulated clinical laboratory environment, of which 3 years or more has been in a predominantly molecular role, including next generation sequencing? If so, list laboratory experience. *

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